skip to main content

Bronchodilator reversibility — SCE Respiratory MCQ

Instant feedback + full explanation. One question, done properly.

EasyRespiratory physiologyBronchodilator reversibilitySCE Respiratory

A 29-year-old woman with intermittent wheeze has spirometry during symptoms. FEV1 is 2.20 L, FVC 3.35 L and FEV1/FVC 0.66 before salbutamol. After salbutamol, FEV1 rises to 2.62 L and FVC is 3.45 L. FeNO is 54 ppb and blood eosinophils are 0.38 × 10^9/L. What is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Asthma with significant bronchodilator reversibility

The FEV1 increase is both substantial in volume and percentage, supporting variable airflow obstruction, and FeNO adds evidence of type 2 airway inflammation. COPD is less likely in a young patient with marked reversibility and eosinophilic markers. Objective testing is central because symptoms alone are unreliable.

Reference: BTS/NICE/SIGN Asthma Guideline 2024; ERS/ATS spirometry standards