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First Pseudomonas isolation in cystic fibrosis — SCE Respiratory MCQ

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ModerateCystic FibrosisFirst Pseudomonas isolation in cystic fibrosisSCE Respiratory

A 19-year-old man with cystic fibrosis has increasing cough and reduced exercise tolerance. Sputum has grown Pseudomonas aeruginosa for the first time. FEV1 has fallen from 82% to 74% predicted. What is the most appropriate management?

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Correct answer: D — Eradication therapy directed against Pseudomonas

First isolation of Pseudomonas in CF should prompt eradication therapy because preventing chronic infection improves long-term outcomes. Waiting for chronic colonisation misses the eradication window. Amoxicillin and fluconazole do not cover Pseudomonas, and airway clearance remains a core component of CF care.

Reference: NICE NG78 Cystic fibrosis; CF Trust standards