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Limited-stage small-cell lung cancer — SCE Respiratory MCQ

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ModerateLung CancerLimited-stage small-cell lung cancerSCE Respiratory

A 62-year-old man with limited-stage small-cell lung cancer has bulky mediastinal nodes but no distant metastases on PET-CT and brain MRI. ECOG performance status is 1 and spirometry is acceptable. What is the most appropriate management?

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Correct answer: D — Concurrent platinum-etoposide chemotherapy and thoracic radiotherapy

Fit patients with limited-stage small-cell lung cancer are generally treated with platinum-etoposide chemotherapy plus thoracic radiotherapy, often concurrently. Surgery is rarely appropriate and not for bulky mediastinal disease. EGFR inhibitors and SABR-alone strategies apply to selected NSCLC contexts, not typical limited-stage SCLC.

Reference: NICE NG122 Lung cancer; ESMO/NICE SCLC guidance