skip to main content

Pulmonary Langerhans cell histiocytosis — SCE Respiratory MCQ

Instant feedback + full explanation. One question, done properly.

ModerateInterstitial Lung DiseasePulmonary Langerhans cell histiocytosisSCE Respiratory

A 41-year-old smoker has progressive dyspnoea and cough. HRCT shows multiple irregular upper-zone cysts and small nodules with sparing of the costophrenic angles. Lung biopsy shows CD1a-positive Langerhans cells. What is the most appropriate management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Smoking cessation with specialist ILD follow-up

Pulmonary Langerhans cell histiocytosis is strongly smoking-associated, and smoking cessation is the key initial intervention with ILD follow-up. Inhaled corticosteroids do not alter disease biology. TB or fungal therapy would not treat biopsy-proven PLCH, and transplantation is reserved for advanced progressive disease.

Reference: ERS/BTS ILD resources; BTS Smoking Cessation resources