FLOT4 Gastric — SCE Medical Oncology MCQ
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Correct answer: C — Perioperative FLOT (fluorouracil/leucovorin/oxaliplatin/docetaxel: 4 cycles pre + 4 cycles post-surgery) significantly improved OS compared with ECF/ECX (median OS 50 vs 35 months) — FLOT is now the standard perioperative regimen for resectable gastric cancer
FLOT4 (Al-Batran et al Lancet 2019): perioperative FLOT vs ECF/ECX for resectable gastric/GOJ adenocarcinoma. OS: 50 vs 35 months. pCR rate: 16% vs 6%. FLOT replaced ECF/ECX as the global standard. NICE recommends FLOT-based perioperative chemotherapy.
Reference: FLOT4 Al-Batran et al Lancet 2019; NICE NG83; ESMO 2024 Gastric