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SNUC — SCE Medical Oncology MCQ

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HardHead & Neck CancerSNUCSCE Medical Oncology

A 62-year-old man with sinonasal undifferentiated carcinoma (SNUC) presents with epistaxis and orbital involvement. This rare H&N tumour has high local aggressiveness. What is the treatment approach?

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Correct answer: D — Multimodal: induction chemotherapy or concurrent CRT ± surgery

SNUC: rare highly aggressive sinonasal tumour. Skull base MDT required. Multimodal treatment: most centres use induction chemo (cisplatin-etoposide or cisplatin-docetaxel) → CRT ± surgical salvage, or upfront craniofacial resection + adjuvant CRT. Prognosis is poor but improving with multimodal approaches. NUT carcinoma is a differential requiring specific testing (NUTM1 rearrangement).

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer