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BRCA2 Pancreatic Cancer — SCE Medical Oncology MCQ

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HardGI CancersBRCA2 Pancreatic CancerSCE Medical Oncology

A patient with germline BRCA2-mutated metastatic pancreatic adenocarcinoma has not progressed after platinum chemotherapy. The MDT says olaparib maintenance is “NICE recommended because of POLO”. Which statement is accurate for NHS England?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: ETA750 was terminated without a NICE recommendation for pancreatic olaparib

Explanation lettering: E = shown as A · C = shown as B · A = shown as C · B = shown as D · D = shown as E

D is correct and separates trial evidence from national commissioning guidance. A mistakes publication for appraisal; B broadens both biomarker and funding criteria; C transfers a technology appraisal across indications; E reverses the maintenance population and invents a funding position.

Reference: NICE TA750 olaparib for metastatic pancreatic cancer: terminated appraisal (Published 1 December 2021; current NICE position): https://www.nice.org.uk/guidance/ta750