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HPRC MET RCC — SCE Medical Oncology MCQ

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HardCancer GeneticsHPRC MET RCCSCE Medical Oncology

A 58-year-old woman with hereditary papillary RCC (germline MET mutation) develops bilateral multifocal papillary RCC. How does management differ?

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Correct answer: A — Nephron-sparing surgery (bilateral disease)

HPRC (MET germline): bilateral, multifocal type 1 papillary. Nephron-sparing surgery when largest reaches 3cm. MET-targeted therapy for metastatic. Standard ICI-based ccRCC regimens less effective.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer