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Trousseau Syndrome — SCE Medical Oncology MCQ

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HardOncological EmergenciesTrousseau SyndromeSCE Medical Oncology

A patient with pancreatic adenocarcinoma develops recurrent migratory superficial thrombophlebitis. Which tumour product most directly contributes to this Trousseau phenotype?

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Correct answer: B — Mucin and tissue-factor procoagulant activity

Mucin-producing adenocarcinomas can activate platelets and coagulation, while tumour tissue factor and inflammatory pathways add thrombin generation. This explains migratory thrombosis as a paraneoplastic hypercoagulable state. Anticoagulant selection is individualised; an outdated blanket claim that LMWH is always preferred was removed.

Reference: https://www.nice.org.uk/guidance/ng158