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ICI MG Assessment — SCE Medical Oncology MCQ

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HardMelanoma & SkinICI MG AssessmentSCE Medical Oncology

A 65-year-old man on ICI develops MG with ptosis and proximal weakness. AchR Ab+. What must be assessed immediately?

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Correct answer: E — Respiratory function (FVC) AND cardiac function (troponin/ECG) — ICI-MG has ~30% overlap with myositis and ~15-25% overlap with myocarditis; the triple overlap has ~50% mortality

ICI-MG: ~30% myositis overlap (CK), ~15-25% myocarditis overlap (troponin). Triple overlap syndrome mortality ~50%. FVC monitoring for myasthenic crisis. ICU admission often warranted.

Reference: ESMO 2024 irAE; Guidon et al JAMA Neurol 2021