skip to main content

Enzalutamide Seizures — SCE Medical Oncology MCQ

Instant feedback + full explanation. One question, done properly.

HardUrological CancersEnzalutamide SeizuresSCE Medical Oncology

A man taking enzalutamide for metastatic castration-resistant prostate cancer has a first generalised seizure. MRI excludes metastasis and PRES; sodium and glucose are normal. Which pharmacological property most plausibly explains the drug-specific contribution?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Central inhibition of GABA-gated chloride-channel activity lowers the seizure threshold

Enzalutamide crosses the blood–brain barrier and is associated with seizures; inhibition of GABA-gated chloride-channel activity is the mechanistic explanation cited in product information. The alternatives describe mechanisms of other syndromes or invent obligatory biochemical abnormalities. A seizure still requires clinical assessment for competing causes rather than automatic attribution.

Reference: Enzalutamide Astellas UK SmPC. https://www.medicines.org.uk/emc/product/10318/smpc