skip to main content

Q-TWiST — SCE Medical Oncology MCQ

Instant feedback + full explanation. One question, done properly.

HardClinical Trials & StatisticsQ-TWiSTSCE Medical Oncology

In a Q-TWiST analysis, mean time with grade 3/4 toxicity (TOX) is 3 months, time without symptoms or toxicity before progression (TWiST) is 12 months, and time after relapse (REL) is 5 months. Utilities are 0.5, 1.0 and 0.25 respectively. What is the quality-adjusted survival?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — 14.75 months

Explanation lettering: D = shown as A · E = shown as C · A = shown as D · C = shown as E

C is correct: (3×0.5)+(12×1.0)+(5×0.25)=1.5+12+1.25=14.75 months. A omits the TOX contribution; B incorrectly rounds or underweights REL; D overweights a non-TWiST state; E is the unweighted total survival.

Reference: Q-TWiST analysis of KEYNOTE-859 (PubMed record, accessed August 2026): https://pubmed.ncbi.nlm.nih.gov/41964430/