Stage IC3 Ovarian Adjuvant — SCE Medical Oncology MCQ

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ModerateGynaecological CancersStage IC3 Ovarian AdjuvantSCE Medical Oncology

A 45-year-old woman with stage IC3 high-grade serous ovarian cancer (positive washings, capsule rupture pre-operatively) undergoes comprehensive staging surgery. What adjuvant therapy is standard?

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Correct answer: E — 6 cycles of carboplatin + paclitaxel

Stage IC3 (positive peritoneal washings) high-grade serous ovarian cancer has approximately 25-35% recurrence risk requiring adjuvant chemotherapy (6 cycles carboplatin-paclitaxel). The distinction between IC1 (intra-operative rupture), IC2 (pre-operative rupture) and IC3 (positive washings) affects prognosis — IC3 has the worst outlook. After completing chemotherapy, PARP inhibitor maintenance eligibility depends on BRCA/HRD testing per standard algorithms. The ICON1 trial supports adjuvant chemotherapy for high-risk early ovarian cancer.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer