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Fertility Recovery BEP — SCE Medical Oncology MCQ

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EasyUrological CancersFertility Recovery BEPSCE Medical Oncology

A 55-year-old man with testicular cancer achieves cure after BEP chemotherapy. At his survivorship appointment, his oncologist discusses fertility. He had pre-treatment sperm banking. What is the expected natural fertility recovery rate after 3-4 cycles of BEP?

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Correct answer: D — Approximately 50-80% of men recover spermatogenesis within 2-5 years of completing BEP chemotherapy

Spermatogenesis recovery after BEP chemotherapy occurs in approximately 50-80% of men within 2-5 years. Recovery depends on: pre-treatment sperm parameters (often already impaired by the tumour itself), number of chemotherapy cycles (3 BEP has better recovery than 4), and individual variation. Semen analysis should be checked at 1-2 year intervals post-treatment. Sperm banking before treatment is strongly recommended as a fertility preservation strategy. Testosterone replacement may be needed if Leydig cell function is impaired.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer