Testicular Cancer Survivorship — SCE Medical Oncology MCQ

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ModerateUrological CancersTesticular Cancer SurvivorshipSCE Medical Oncology

A 55-year-old man with testicular cancer has completed 3 cycles of BEP and achieved marker normalisation and radiographic CR. He is entering long-term survivorship follow-up. What are the key late effects of cisplatin-based chemotherapy that require lifelong monitoring?

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Correct answer: D — Cardiovascular disease (2× risk)

Testicular cancer survivors after cisplatin-based chemotherapy have increased long-term risks: cardiovascular disease (MI, stroke — 2× population risk), second malignancies (leukaemia, solid tumours — 1.5-2× risk), persistent nephrotoxicity (reduced GFR), ototoxicity (irreversible), hypogonadism (infertility, testosterone deficiency), metabolic syndrome, peripheral neuropathy and psychological effects (anxiety, cancer distress). ESMO/NICE recommend structured survivorship follow-up including CV risk assessment, metabolic monitoring, audiometry and psychosocial support.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer