A 40-year-old man with low-grade glioma (IDH-mutant, 1p/19q intact astrocytoma, WHO grade 2) undergoes subtotal resection. Post-operative MRI shows

Question

A 40-year-old man with low-grade glioma (IDH-mutant, 1p/19q intact astrocytoma, WHO grade 2) undergoes subtotal resection. Post-operative MRI shows residual tumour. He has no neurological deficits and is neurologically stable. Two management strategies are debated: immediate adjuvant treatment versus watchful waiting with treatment at progression. What does the EORTC 22845 trial inform?

Accepted Answer

The EORTC 22845 trial showed early RT improved PFS but NOT OS compared with deferred RT at progression

Answer

Radiotherapy causes glioma transformation as the preferred next management strategy in this patient

Answer

Chemotherapy is always preferred over RT as the preferred next management strategy in this patient

Answer

The trial was never completed as the preferred next management strategy in this patient

Answer

Immediate radiotherapy is always better as the preferred next management strategy in this patient

Low-grade Glioma Timing — SCE Medical Oncology MCQ