A 55-year-old woman is diagnosed with stage IIIC1 high-grade serous ovarian cancer. She is being considered for primary debulking surgery (PDS)

Question

A 55-year-old woman is diagnosed with stage IIIC1 high-grade serous ovarian cancer. She is being considered for primary debulking surgery (PDS) versus neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). What patient selection factors favour NACT over PDS?

Accepted Answer

NACT is preferred when complete cytoreduction at PDS is unlikely (large-volume upper abdominal disease

Answer

NACT is always inferior to PDS as the preferred next management strategy in this patient

Answer

All patients should have PDS regardless of disease burden as the preferred next management strategy

Answer

BRCA status determines PDS vs NACT as the preferred next management strategy in this patient

Answer

NACT is preferred for all stage III/IV as the preferred next management strategy in this patient

PDS vs NACT Ovarian — SCE Medical Oncology MCQ

A 55-year-old woman is diagnosed with stage IIIC1 high-grade serous ovarian cancer. She is being considered for primary debulking surgery (PDS) versus neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). What patient selection factors favour NACT over PDS?