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Cervical Cancer Sedlis Peters — SCE Medical Oncology MCQ

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ModerateGynaecological CancersCervical Cancer Sedlis PetersSCE Medical Oncology

A 62-year-old woman with stage IB1 cervical cancer (2 cm squamous cell carcinoma, no LVSI, depth of invasion 5 mm) undergoes radical hysterectomy with pelvic lymph node dissection. All nodes are negative. Final pathology shows clear margins. Does she need adjuvant treatment?

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Correct answer: E — No adjuvant treatment needed

Post-operative adjuvant therapy for cervical cancer is guided by risk criteria: HIGH-RISK (Peters criteria: positive margins, positive nodes, parametrial involvement) → adjuvant chemoradiotherapy. INTERMEDIATE-RISK (Sedlis criteria: combinations of LVSI, stromal invasion depth, tumour size) → adjuvant radiotherapy alone. This patient has small tumour, no LVSI, negative margins and negative nodes — she does not meet Sedlis intermediate-risk criteria and requires no adjuvant treatment, only surveillance.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer