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MASCC Score — SCE Medical Oncology MCQ

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ModerateOncological EmergenciesMASCC ScoreSCE Medical Oncology

A 65-year-old man presents with acute neutropenic sepsis (temperature 39.2°C, neutrophils 0.1 × 10⁹/L) 10 days after chemotherapy. He has a Hickman line. Blood cultures are drawn. The MASCC risk score is calculated at 15 (low risk ≥21). What does the low MASCC score indicate?

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Correct answer: DA MASCC score <21 indicates HIGH-risk neutropenic sepsis with predicted >10% complication rate

The MASCC (Multinational Association for Supportive Care in Cancer) risk index stratifies febrile neutropenia patients: score ≥21 = low risk (suitable for early discharge/oral antibiotics in selected patients); score <21 = high risk (requiring inpatient IV antibiotics). The score incorporates: burden of illness, hypotension, COPD, solid tumour vs haematological malignancy, dehydration, outpatient status and age. A low MASCC score indicates high-risk FN requiring aggressive management. NICE CG151 recommends using a validated risk-scoring tool.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer