A 52-year-old woman with early breast cancer (pT1c N0 ER+/HER2-) has a Ki-67 of 35%. Her oncologist discusses the prognostic significance. What does

Question

A 52-year-old woman with early breast cancer (pT1c N0 ER+/HER2-) has a Ki-67 of 35%. Her oncologist discusses the prognostic significance. What does high Ki-67 indicate?

Accepted Answer

High Ki-67 (>20-30%) indicates high tumour proliferation rate and is associated with higher recurrence risk and chemotherapy benefit

Answer

Ki-67 >10% is always low risk as the preferred next management strategy at this stage in the clinical context described

Answer

Ki-67 is not clinically useful as the preferred next management strategy at this stage in the clinical context described

Answer

Ki-67 only matters in TNBC as the preferred next management strategy at this stage in the clinical context described

Answer

Ki-67 predicts endocrine therapy resistance only as the preferred next management strategy in this patient

Ki-67 Breast Cancer — SCE Medical Oncology MCQ

A 52-year-old woman with early breast cancer (pT1c N0 ER+/HER2-) has a Ki-67 of 35%. Her oncologist discusses the prognostic significance. What does high Ki-67 indicate?