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Cowden Syndrome — SCE Medical Oncology MCQ

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HardCancer GeneticsCowden SyndromeSCE Medical Oncology

A 41-year-old PTEN pathogenic-variant carrier has no previous cancer. Which surveillance pairing matches the European/UKCGG-hosted guideline?

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Correct answer: B — Renal ultrasound every 2 years from 40 and annual breast MRI from 30

The guideline recommends annual breast MRI from 30 and renal ultrasound every two years from 40. It also recommends annual thyroid ultrasound from 18. Routine ionising whole-body imaging and annual endometrial biopsy are not the surveillance standard.

Reference: Cancer surveillance guideline for PTEN hamartoma tumour syndrome. https://www.ukcgg.org/media/11951/pten-european-guideline.pdf