Cisplatin Ototoxicity Survivorship — SCE Medical Oncology MCQ
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Correct answer: D — Permanent cumulative cochlear injury requiring formal audiological rehabilitation
Cisplatin causes cumulative, usually irreversible outer-hair-cell injury, so formal audiological assessment and rehabilitation are appropriate. Permanent neural auditory injury requiring central auditory-processing rehabilitation: central processing loss has a different audiological pattern from cisplatin cochleotoxicity. Permanent ossicular injury requiring reconstructive middle-ear surgery: ossicular disease causes conductive rather than high-frequency sensorineural loss. Permanent vestibular injury requiring balance and gaze-stabilisation rehabilitation: vestibular toxicity primarily causes disequilibrium rather than the stated audiogram. Permanent autoimmune cochleitis requiring systemic immunosuppressive treatment: the exposure and bilateral high-frequency pattern favour direct cisplatin injury.
Reference: Cisplatin 1 mg/mL UK summary of product characteristics (Current UK SmPC, accessed July 2026): https://www.medicines.org.uk/emc/product/100546/smpc