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Granulosa Cell Tumour — SCE Medical Oncology MCQ

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ModerateGynaecological CancersGranulosa Cell TumourSCE Medical Oncology

A 50-year-old woman presents with a unilateral solid ovarian mass. Intra-operative frozen section shows a granulosa cell tumour (adult type). She has completed childbearing. What is the standard surgical management?

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Correct answer: D — Total hysterectomy, bilateral salpingo-oophorectomy, comprehensive staging (peritoneal washings, omentectomy, peritoneal biopsies)

Adult granulosa cell tumour (GCT) is a sex cord-stromal tumour that secretes oestrogen and inhibin B (tumour markers). Standard surgical management for patients who have completed childbearing is TAH-BSO with comprehensive staging. GCTs have an indolent but persistent course — late recurrences (>10 years) are common. Inhibin B is the most sensitive tumour marker for surveillance. Adjuvant chemotherapy (BEP or carboplatin-paclitaxel) is considered for stage IC and above. Hormonal therapy (aromatase inhibitors) has activity in recurrent disease.

Reference: ESMO 2024 Ovarian Sex Cord-Stromal Tumour Guidelines; NICE NG