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Ovarian Germ Cell Tumour — SCE Medical Oncology MCQ

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ModerateGynaecological CancersOvarian Germ Cell TumourSCE Medical Oncology

A 28-year-old woman is diagnosed with a stage IC immature teratoma of the ovary (grade 2). She undergoes unilateral salpingo-oophorectomy with comprehensive staging (peritoneal biopsies, omentectomy, pelvic/para-aortic LN sampling). AFP was mildly elevated pre-operatively and normalises post-surgery. What adjuvant therapy is recommended?

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Correct answer: E — Adjuvant BEP chemotherapy (3-4 cycles)

Ovarian immature teratoma stage IC or grade 2-3 requires adjuvant platinum-based chemotherapy (BEP × 3-4 cycles), analogous to testicular germ cell tumour protocols. Stage IA grade 1 immature teratoma can be managed with surveillance alone. Fertility-sparing surgery (USO) is appropriate for young women with unilateral disease. AFP monitoring post-chemotherapy is essential. Cure rates exceed 90% with appropriate chemotherapy.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer