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Breast Cancer — SCE Medical Oncology MCQ

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HardBreast CancerBreast CancerSCE Medical Oncology

A 68-year-old woman with ER+/HER2- early breast cancer (pT2 N0, grade 2) is assessed using the CTS5 (Clinical Treatment Score post-5 years) tool after completing 5 years of tamoxifen. Her CTS5 score predicts a high late recurrence risk (>10% at 5-10 years). What does this tool specifically assess?

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Correct answer: BRisk of late distant recurrence (years 5-10) to guide extended endocrine therapy decisions

CTS5 integrates tumour size, nodal status, grade, age and endocrine therapy type to estimate late distant recurrence risk (years 5-10) in ER+ breast cancer. Unlike Oncotype DX (which guides early chemotherapy decisions), CTS5 specifically addresses whether to extend endocrine therapy beyond 5 years. High CTS5 scores (≥3.86) identify women who benefit most from extended AI therapy.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer