Breast Cancer — SCE Medical Oncology MCQ
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Correct answer: B — Risk of late distant recurrence (years 5-10) to guide extended endocrine therapy decisions
CTS5 integrates tumour size, nodal status, grade, age and endocrine therapy type to estimate late distant recurrence risk (years 5-10) in ER+ breast cancer. Unlike Oncotype DX (which guides early chemotherapy decisions), CTS5 specifically addresses whether to extend endocrine therapy beyond 5 years. High CTS5 scores (≥3.86) identify women who benefit most from extended AI therapy.
Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer