A 30-year-old man diagnosed with stage IS non-seminomatous germ cell tumour (right orchidectomy performed, markers declining but not yet normal — AFP

Question

A 30-year-old man diagnosed with stage IS non-seminomatous germ cell tumour (right orchidectomy performed, markers declining but not yet normal — AFP 45 ng/mL, HCG 8 IU/L, LDH normal). CT staging is clear. What does stage IS indicate and what is the management?

Accepted Answer

Stage IS — marker elevation post-orchidectomy indicating occult metastatic disease; treat with BEP × 3 (good risk)

Answer

Stage IS — re-check markers in 6 months

Answer

Stage IS — persistently elevated markers post-orchidectomy without radiographic disease; treat with surveillance only

Answer

Stage IS — indicates seminoma regardless of histology

Answer

Stage IS — requires immediate RPLND

Testicular Cancer — SCE Medical Oncology MCQ

A 30-year-old man diagnosed with stage IS non-seminomatous germ cell tumour (right orchidectomy performed, markers declining but not yet normal — AFP 45 ng/mL, HCG 8 IU/L, LDH normal). CT staging is clear. What does stage IS indicate and what is the management?