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Gastric Cancer — SCE Medical Oncology MCQ

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EasyGI CancersGastric CancerSCE Medical Oncology

A 55-year-old man with gastric adenocarcinoma (cT3 N2 M0, HER2-negative, MSS) is planned for curative-intent surgery. What perioperative chemotherapy is standard in the UK?

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Correct answer: A — Neoadjuvant FLOT 4 cycles pre-op and 4 cycles post-op

The FLOT4 trial demonstrated that perioperative FLOT (4 cycles pre-op + 4 cycles post-op) significantly improved OS compared with perioperative ECF/ECX in resectable gastric/GOJ adenocarcinoma. FLOT has replaced ECF/ECX as the standard perioperative regimen in the UK and Europe. Completion of adjuvant FLOT cycles post-surgery is recommended if the patient recovers adequately.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer