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Cancer-related Fatigue — SCE Medical Oncology MCQ

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EasySupportive & Palliative OncologyCancer-related FatigueSCE Medical Oncology

A 72-year-old man with incurable metastatic colorectal cancer is experiencing severe cancer-related fatigue that is limiting his daily activities. He has been screened for anaemia (Hb 128 g/L), hypothyroidism, depression and infection — all negative. What non-pharmacological intervention has the strongest evidence for cancer-related fatigue?

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Correct answer: D — Structured exercise programme (aerobic + resistance training)

Structured exercise (combination of moderate-intensity aerobic and resistance training) has the strongest evidence base for managing cancer-related fatigue, supported by multiple systematic reviews and meta-analyses (Cochrane review, UK oncology guidance guidelines). Even in patients receiving active treatment, supervised exercise improves fatigue, functional capacity and quality of life. Pharmacological interventions (methylphenidate, modafinil) have weaker evidence. Complete bed rest worsens deconditioning and fatigue.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer