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Ovarian Cancer — SCE Medical Oncology MCQ

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HardGynaecological CancersOvarian CancerSCE Medical Oncology

A patient with germline BRCA1-mutated high-grade serous ovarian cancer has responded to platinum chemotherapy for a second platinum-sensitive relapse and has now completed at least two platinum-containing courses. Which maintenance option is recommended by NICE?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Olaparib maintenance after the documented platinum response

NICE TA908 recommends olaparib maintenance for relapsed platinum-sensitive high-grade ovarian, fallopian-tube or primary peritoneal cancer that has responded to platinum, carries a BRCA1/2 mutation and has received at least two platinum courses. The question tests the treatment consequence rather than an outdated six-month label alone.

Reference: NICE TA908 olaparib maintenance for relapsed platinum-sensitive ovarian cancer (Published July 2023): https://www.nice.org.uk/guidance/ta908/chapter/1-Recommendations