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Neuroendocrine Tumour — SCE Medical Oncology MCQ

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HardGI CancersNeuroendocrine TumourSCE Medical Oncology

A 2 cm grade-1 terminal-ileal neuroendocrine tumour was removed during emergency surgery, but the specimen contains no mesentery or lymph nodes. Staging shows no distant disease. What should the specialist NET MDT consider next?

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Correct answer: DCompletion oncological bowel resection with associated mesenteric lymph-node dissection

Explanation lettering: B = shown as A · A = shown as B · E = shown as D · D = shown as E

E is correct. Small-intestinal NETs have a substantial rate of regional nodal disease even when the primary is small and non-functioning. UKINETS and BSG guidance supports resection of the primary with the associated mesenteric lymphatic field, while preserving bowel and mesenteric blood supply. Biochemical silence does not establish complete regional treatment. Somatostatin analogues and everolimus control unresectable or metastatic disease but do not replace oncological resection in this localised setting. Capecitabine-temozolomide is not routine adjuvant therapy for a completely resectable grade-1 ileal NET.

Reference: UKINETS and BSG gastroenteropancreatic NET guideline: https://gut.bmj.com/content/61/1/6