A 50-year-old man on ICU with cirrhosis has AKI. His creatinine is 250 µmol/L. Why might serum creatinine underestimate the severity of AKI in cirrhos...

Question

A 50-year-old man on ICU with cirrhosis has AKI. His creatinine is 250 µmol/L. Why might serum creatinine underestimate the severity of AKI in cirrhosis?

Accepted Answer

Cirrhotic patients have reduced creatinine production (sarcopenia, reduced hepatic creatine-to-creatinine conversion) and increased volume of distribution (ascites, oedema) that dilutes creatinine - a creatinine of 250 in cirrhosis may represent much worse renal function than in a non-cirrhotic patient

Answer

Creatinine is always accurate

Answer

Creatinine is metabolised faster

Answer

Bilirubin interferes with the assay

Answer

Only reflects tubular function

uk-fficm MCQ (SBA): Creatinine in Cirrhosis

A 50-year-old man on ICU with cirrhosis has AKI. His creatinine is 250 µmol/L. Why might serum creatinine underestimate the severity of AKI in cirrhosis?