A 52-year-old man on ICU has confirmed invasive pulmonary aspergillosis. He is on IV voriconazole. What monitoring is essential?...

Question

A 52-year-old man on ICU has confirmed invasive pulmonary aspergillosis. He is on IV voriconazole. What monitoring is essential?

Accepted Answer

Voriconazole trough TDM (target 1-5.5 mg/L), liver function tests (hepatotoxicity in 10-20%), visual disturbance assessment (transient changes in 30%), QTc monitoring, and drug interaction review (potent CYP2C19/3A4 inhibitor)

Answer

No monitoring needed

Answer

Renal function only

Answer

FBC only

Answer

Daily CXR only

uk-fficm MCQ (SBA): Voriconazole Monitoring

A 52-year-old man on ICU has confirmed invasive pulmonary aspergillosis. He is on IV voriconazole. What monitoring is essential?