A 55-year-old man on ICU is receiving IV adrenaline infusion at 0.1 mcg/kg/min for cardiogenic shock. At this dose, what are the predominant adrenergi...

Question

A 55-year-old man on ICU is receiving IV adrenaline infusion at 0.1 mcg/kg/min for cardiogenic shock. At this dose, what are the predominant adrenergic receptor effects?

Accepted Answer

At low doses (0.01-0.1 mcg/kg/min), adrenaline predominantly stimulates beta-1 (positive inotropy and chronotropy) and beta-2 (vasodilation, bronchodilation) receptors; at higher doses (>0.1 mcg/kg/min), alpha-1 vasoconstriction becomes increasingly prominent

Answer

Alpha-1 vasoconstriction only

Answer

Beta-2 effects only at all doses

Answer

Adrenaline has no dose-dependent receptor selectivity

Answer

Dopaminergic effects at all doses

uk-fficm MCQ (SBA): Adrenaline - Dose-Dependent Effects

A 55-year-old man on ICU is receiving IV adrenaline infusion at 0.1 mcg/kg/min for cardiogenic shock. At this dose, what are the predominant adrenergic receptor effects?