A 50-year-old woman on ICU has severe hospital-acquired pneumonia. The microbiologist recommends 'beta-lactam therapeutic drug monitoring' to optimise...

Question

A 50-year-old woman on ICU has severe hospital-acquired pneumonia. The microbiologist recommends 'beta-lactam therapeutic drug monitoring' to optimise meropenem dosing. What pharmacokinetic target is used for beta-lactam TDM?

Accepted Answer

Free drug concentration above the MIC for at least 50-100% of the dosing interval (fT>MIC) - for critically ill patients, targets of 100% fT>MIC or even fCmin >4-8x MIC are recommended to optimise bactericidal activity

Answer

Peak:MIC ratio

Answer

AUC/MIC only

Answer

Trough level alone without reference to MIC

Answer

Beta-lactam TDM is never performed

uk-fficm MCQ (SBA): Beta-Lactam TDM

A 50-year-old woman on ICU has severe hospital-acquired pneumonia. The microbiologist recommends 'beta-lactam therapeutic drug monitoring' to optimise meropenem dosing. What pharmacokinetic target is used for beta-lactam TDM?