A 55-year-old man on ICU has severe AKI requiring CRRT. His weight is 90 kg. The team prescribes CVVHDF with an effluent dose of 25 mL/kg/hr. He is re...

Question

A 55-year-old man on ICU has severe AKI requiring CRRT. His weight is 90 kg. The team prescribes CVVHDF with an effluent dose of 25 mL/kg/hr. He is receiving IV vancomycin, IV meropenem, and enteral levetiracetam. Which antibiotic is LEAST affected by CRRT and unlikely to require significant dose adjustment?

Accepted Answer

Teicoplanin - it has high protein binding (~90%), large volume of distribution, and hepatic/renal mixed elimination, making it relatively resistant to CRRT removal

Answer

Vancomycin

Answer

Meropenem

Answer

Levetiracetam

Answer

All drugs are equally removed by CRRT

uk-fficm MCQ (SBA): Drug Dosing in CRRT