latanoprost + netarsudil mesylate at a glance
Medicine class
Prostaglandin analogue plus Rho kinase inhibitor
Contact lenses
Remove before application and wait 15 minutes before reinserting
Preservative
Contains benzalkonium chloride, which may irritate dry eyes, affect the cornea and discolour soft lenses
What is latanoprost + netarsudil mesylate used for?
Licensed in adults to reduce raised eye pressure when a prostaglandin or netarsudil alone has not provided sufficient reduction.
Primary open-angle glaucoma
Ocular hypertension
How does latanoprost + netarsudil mesylate work?
Both ingredients improve fluid drainage from the eye. Latanoprost mainly increases uveoscleral drainage, while netarsudil increases trabecular drainage and may reduce pressure in the episcleral veins.
latanoprost + netarsudil mesylate preparations and strengths
Eye drops
Route: Ophthalmic
Strengths: 50 micrograms/mL + 200 micrograms/mL
How to take latanoprost + netarsudil mesylate
Use only in the eye and follow the supplied leaflet and ophthalmology instructions.
Wash your hands and remove contact lenses.
Do not let the bottle tip touch the eye, eyelids, fingers or another surface.
After application, close the eye and gently press the inner corner beside the nose for about one minute.
Wait until temporary blurred vision clears before driving or using machinery.
latanoprost + netarsudil mesylate side effects
Common or expected effects
- Eye redness
- Pain, stinging or discomfort when applied
- Fine whorl-like corneal deposits, usually without an apparent effect on vision
- Gradual iris darkening, which may be permanent
- Longer, thicker or darker eyelashes
- Itching, irritation, watering or dry eye
- Temporary blurred or reduced vision
- Eyelid redness, swelling or crusting
Get urgent medical advice
- Reduced vision or eye pain, particularly after previous eye surgery or with corneal swelling
- Severe or persistent eye inflammation
- Wheezing, breathlessness or worsening asthma
- Chest pain
- Symptoms of a serious allergic reaction
latanoprost + netarsudil mesylate in pregnancy
The product-specific UK SmPC says this combination should not be used during pregnancy. Tell the ophthalmology and maternity teams if pregnant or planning pregnancy; do not stop glaucoma treatment without advice.
latanoprost + netarsudil mesylate while breastfeeding
Netarsudil transfer into human milk is unknown, and latanoprost or its metabolites may enter milk. A prescriber should weigh the benefits of breastfeeding against the need for this combination and discuss alternatives where appropriate.
latanoprost + netarsudil mesylate interactions
Clinically important interactions mainly involve other treatments applied to the eye.
Other prostaglandins or prostaglandin analogues
Using more than one may paradoxically increase eye pressure, so the combination is not recommended.
Eye drops containing thiomersal
Direct mixing can cause precipitation.
Common questions about latanoprost + netarsudil mesylate
Answers are fully visible for fast scanning and source review.
Can it permanently change eye colour?
Yes. Latanoprost can gradually increase brown iris pigment, and the change may be permanent, especially in mixed-colour eyes.
Why can it make the eye red?
Netarsudil widens small surface blood vessels. Eye redness is very common and often mild, although persistent or troublesome redness should be reviewed.
Can I wear contact lenses?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.