landiolol hydrochloride at a glance
Medicine class
Selective beta-1 blocker
Usual setting
Short-term treatment in monitored hospital care
Administration
Continuous intravenous infusion prepared and given by a healthcare professional
Monitoring
Continuous ECG and blood-pressure monitoring are advised
What is landiolol hydrochloride used for?
Licensed adult uses include:
Supraventricular tachycardia, including rapid ventricular-rate control in atrial fibrillation or atrial flutter when short-term control is required.
Non-compensatory sinus tachycardia when the clinician considers that the rapid heart rate itself requires intervention.
How does landiolol hydrochloride work?
It selectively blocks beta-1 receptors in the heart, slowing heart rate, abnormal pacemaker activity and conduction through the atrioventricular node. Plasma esterases rapidly break it down, so its effects usually diminish quickly after the infusion is changed or stopped.
landiolol hydrochloride preparations and strengths
Solution for infusion
Route: Intravenous
Strengths: 300 mg
How to take landiolol hydrochloride
It is not taken by mouth. A healthcare professional reconstitutes the powder and gives it through a central or peripheral intravenous line in a monitored setting.
It should not share an intravenous line with other medicines.
Only a clear, colourless reconstituted solution should be used.
Food does not affect administration because it is given intravenously.
landiolol hydrochloride side effects
Common or expected effects
- Low blood pressure
- Slow heartbeat
Get urgent medical advice
- Severe hypotension, shock or loss of consciousness
- Severe bradycardia, heart block, sinus arrest or cardiac arrest
- Bronchospasm, severe breathing difficulty or low oxygen levels
- Pulmonary oedema or marked worsening of cardiac function
- Seizure or signs of reduced blood flow to the brain
landiolol hydrochloride in pregnancy
Human pregnancy information is limited, so avoidance is advised as a precaution. If specialist treatment is necessary, maternal circulation, uteroplacental blood flow and fetal growth may require monitoring; the newborn should be observed for slow heart rate, low blood pressure or low blood glucose.
landiolol hydrochloride while breastfeeding
It is unknown whether landiolol enters human milk, and risk to a breastfed infant cannot be excluded. The specialist should weigh urgent maternal treatment against breastfeeding benefits; general beta-blocker guidance does not establish landiolol as a preferred option.
landiolol hydrochloride interactions
Clinicians should review all medicines because combinations affecting heart rate, conduction or blood pressure may require closer monitoring.
Verapamil or diltiazem
May excessively slow the heart or impair atrioventricular conduction; concomitant use is not recommended when conduction abnormalities are present.
Amiodarone, class I antiarrhythmics or digoxin
Can add to suppression of cardiac function and electrical conduction.
Other antihypertensives or inhaled anaesthetics
May increase the risk of clinically important hypotension.
Common questions about landiolol hydrochloride
Answers are fully visible for fast scanning and source review.
Why is landiolol hydrochloride given in hospital?
It requires intravenous administration, individual adjustment and continuous monitoring of heart rhythm and blood pressure.
Is it used for long-term heart-rate control?
No. Its licence is for short-term control in acute or perioperative circumstances, not chronic treatment.
Can it be used in asthma?
It is contraindicated during an acute asthma attack. Other bronchospastic disease requires careful specialist assessment because bronchospasm can still occur despite beta-1 selectivity.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.