Answer
Landiolol hydrochloride undergoes ester hydrolysis, mainly in plasma by pseudocholinesterases and carboxylesterases, producing a ketal subsequently cleaved to glycerol and acetone, and metabolite M1, which undergoes beta-oxidation to metabolite M2.
Sources for this answer
- Rapibloc 300 mg powder for solution for infusionAOP Orphan Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 5Document updated
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