hydrochlorothiazide + telmisartan at a glance
Medicine class
Angiotensin II receptor blocker plus thiazide diuretic
Main licensed use
High blood pressure not adequately controlled by telmisartan alone
Food
May be taken with or without food and swallowed with liquid
Important precaution
Protect skin from excessive sunlight and report suspicious new or changing lesions
What is hydrochlorothiazide + telmisartan used for?
The selected product is licensed for:
Essential hypertension in adults whose blood pressure is not adequately controlled by telmisartan alone.
How does hydrochlorothiazide + telmisartan work?
Telmisartan blocks AT1 receptors, reducing angiotensin II–driven narrowing of blood vessels and aldosterone effects. Hydrochlorothiazide increases sodium and water excretion by the kidneys. Together, they produce an additive reduction in blood pressure.
hydrochlorothiazide + telmisartan preparations and strengths
Tablet
Route: Oral
Strengths: 40 mg + 12.5 mg, 80 mg + 12.5 mg, 80 mg + 25 mg
How to take hydrochlorothiazide + telmisartan
Swallow the tablet with water or another non-alcoholic drink, with or without food. Remove it from its moisture-protective blister shortly before use. If dizziness occurs, avoid driving or operating machinery.
Tell healthcare professionals about this treatment before surgery, anaesthesia or iodinated contrast imaging.
hydrochlorothiazide + telmisartan side effects
Common or expected effects
- Dizziness
- Nausea
- Low blood magnesium
Get urgent medical advice
- Swelling of the face, lips, tongue or throat, or breathing difficulty
- Severe shortness of breath, fever, weakness or confusion
- Sudden eye pain, blurred vision or loss of vision
- Severe blistering, peeling or widespread rash
- Fainting, marked weakness, confusion, muscle cramps or abnormal heartbeat
- Reduced urine output or other signs of acute kidney injury
- New or changing skin or lip lesions
hydrochlorothiazide + telmisartan in pregnancy
This combination is not recommended in early pregnancy and is contraindicated during the second and third trimesters because angiotensin receptor blockers can harm fetal kidney function and development. Contact the prescriber promptly if pregnancy is planned or confirmed; later-pregnancy exposure may require specialist fetal monitoring.
hydrochlorothiazide + telmisartan while breastfeeding
This combination is not recommended during breastfeeding because direct evidence is limited and better-established alternatives are usually preferred, particularly for newborn or premature infants. If considered essential, specialist assessment should include both components and monitoring of the infant for poor feeding, lethargy, pallor, inadequate weight gain or reduced urine output.
hydrochlorothiazide + telmisartan interactions
Check prescribed, over-the-counter and complementary products with a pharmacist or prescriber. Important examples include:
Lithium
Lithium concentrations and toxicity may increase; concurrent use is generally not recommended and requires close monitoring if unavoidable.
ACE inhibitors or aliskiren
Combining renin–angiotensin system blockers increases the risk of hypotension, high potassium and kidney injury; some combinations are contraindicated.
NSAIDs such as ibuprofen
They may weaken the blood-pressure-lowering effect and increase kidney injury risk, especially with dehydration or existing renal impairment.
Common questions about hydrochlorothiazide + telmisartan
Answers are fully visible for fast scanning and source review.
What is hydrochlorothiazide + telmisartan used for?
It treats essential hypertension in adults when telmisartan alone has not lowered blood pressure adequately.
How does hydrochlorothiazide + telmisartan lower blood pressure?
Telmisartan relaxes blood vessels by blocking angiotensin II, while hydrochlorothiazide helps the kidneys remove sodium and water.
Can it be taken with food?
Yes. The tablet may be taken with or without food and swallowed with a non-alcoholic drink.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.