human fibrinogen + human thrombin at a glance
Medicine class
Local haemostatic fibrin sealant
Where it is used
On the surface of bleeding tissue during an operation; it must not be injected into blood vessels.
Who administers it
An experienced surgeon trained in its use.
Age range
Licensed for all age groups.
What is human fibrinogen + human thrombin used for?
Licensed as supportive treatment during surgery when standard techniques are insufficient.
Improving local control of bleeding at a tissue surface.
Supporting sutures in vascular surgery.
How does human fibrinogen + human thrombin work?
Thrombin converts fibrinogen into fibrin. The fibrin strands join and cross-link to form a local clot over the treated surface. Normal body processes later break down and clear the clot.
How to take human fibrinogen + human thrombin
This is not self-administered. A trained surgeon applies both components together to a dried tissue surface using the supplied applicator, by dripping or spraying as appropriate. It should form a thin layer.
Do not inject or apply it inside a blood vessel.
Spraying requires the specified device and a safe distance from tissue.
Healthcare professionals thaw and prepare this single-use product.
human fibrinogen + human thrombin side effects
Common or expected effects
- Nausea
- Itching
- Pain related to the surgical procedure
Get urgent medical advice
- Severe allergic reaction, including swelling, wheezing, chest tightness, low blood pressure or collapse
- Blood clots if the product enters a blood vessel, potentially including deep-vein thrombosis, pulmonary embolism or disseminated intravascular coagulation
- Postoperative infection, abscess, wound breakdown, bile leak or significant postoperative bleeding
human fibrinogen + human thrombin in pregnancy
Controlled pregnancy studies are unavailable. It should be used only when the surgical and obstetric teams consider it clearly needed. Because it is made from human plasma, the residual risk from transmissible agents—particularly parvovirus B19—should also be considered.
human fibrinogen + human thrombin while breastfeeding
Safety during breastfeeding has not been established in controlled studies. The surgical team should use it only when clearly needed after considering the clinical circumstances.
human fibrinogen + human thrombin interactions
Formal medicine-interaction studies have not been performed. The main recognised issue is contact with certain substances at the operative site.
Antiseptic solutions containing alcohol, iodine or heavy metals
Contact may denature the sealant and reduce its effectiveness, so these substances should be removed from the application area as far as possible.
Common questions about human fibrinogen + human thrombin
Answers are fully visible for fast scanning and source review.
Is it injected into the bloodstream?
No. It is applied only to the tissue surface. Intravascular application is contraindicated because it may cause dangerous blood clots.
Does it replace stitches?
Not generally. It may support sutures in vascular surgery, but evidence is inadequate for using it simply as a tissue glue.
Can it stop severe arterial bleeding?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.