gozetotide at a glance
Medicine class
PSMA-targeted diagnostic radiopharmaceutical
Usual role
Finding PSMA-positive lesions in adults with prostate cancer during PET imaging
Administration
Prepared with gallium-68 and injected into a vein by trained nuclear medicine staff
Preparation
Drink plenty of water and follow the imaging department's instructions
What is gozetotide used for?
Its licensed use is diagnostic only.
Identifying PSMA-positive lesions by PET in adults with prostate cancer.
How does gozetotide work?
Gozetotide binds to PSMA on cell surfaces. Once labelled with gallium-68, areas containing PSMA emit signals detected by a PET scanner. Uptake is not unique to prostate cancer, so specialists interpret the scan alongside other clinical and diagnostic information.
How to take gozetotide
Gozetotide is not taken at home. It is radiolabelled and given by slow intravenous injection in a designated nuclear medicine facility.
Drink plenty of water before attending unless your clinical team has restricted your fluids.
Empty your bladder when instructed and urinate frequently afterwards to help reduce radiation exposure.
Take regular medicines as usual unless the imaging department instructs otherwise.
Tell the department beforehand about possible pregnancy, breastfeeding, difficult veins, claustrophobia or difficulty lying flat.
gozetotide side effects
Common or expected effects
- Fatigue.
- Nausea, constipation, vomiting, diarrhoea, dry mouth, chills or an injection-site reaction such as warmth or bruising are uncommon.
Get urgent medical advice
- Severe hypersensitivity symptoms such as breathing difficulty, facial or throat swelling or collapse require immediate help.
- Report pain, swelling or marked irritation around the injection site promptly, as leakage outside the vein can cause local irritation and affect imaging.
gozetotide in pregnancy
The licensed product is not indicated for females, and pregnancy data are unavailable. Because radiopharmaceuticals can harm an unborn baby, anyone who could be pregnant must tell the imaging department before the scan for specialist assessment.
gozetotide while breastfeeding
Effects on a breastfed child and milk production have not been studied. Tell the nuclear medicine department in advance; it will provide instructions about expressing milk, temporarily interrupting feeding and contact precautions.
gozetotide interactions
Clinically significant medicine interactions are not expected, but give the imaging team a current medicines list.
Other prescribed and non-prescribed medicines
No clinically significant interactions are expected from laboratory data. Regular medicines can generally be taken unless the imaging department advises otherwise.
CYP450 substrates, inhibitors or inducers
Gozetotide is not expected to alter or be materially affected through CYP450 pathways.
Common questions about gozetotide
Answers are fully visible for fast scanning and source review.
Is gozetotide a treatment for prostate cancer?
No. It is a diagnostic imaging agent used to locate PSMA-positive lesions; it does not destroy or control cancer cells.
How is gozetotide given?
It is prepared with gallium-68 and injected slowly into a vein by trained nuclear medicine staff.
Can I take my usual medicines beforehand?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.