fluticasone furoate + umeclidinium bromide + vilanterol trifenatate at a glance
Medicine class
Inhaled corticosteroid, long-acting muscarinic antagonist and long-acting beta₂ agonist (ICS/LAMA/LABA).
Inhaler type
Pre-dispensed dry powder delivered through an Ellipta inhaler.
Sudden symptoms
It does not replace a quick-acting reliever inhaler for sudden breathlessness or wheezing.
Excipients
Contains lactose; certain rare inherited sugar-intolerance disorders preclude use.
What is fluticasone furoate + umeclidinium bromide + vilanterol trifenatate used for?
Licensed use:
Maintenance treatment of moderate to severe COPD in adults whose condition is not adequately controlled by specified inhaled corticosteroid/long-acting beta₂ agonist or long-acting beta₂ agonist/long-acting muscarinic antagonist combinations.
How does fluticasone furoate + umeclidinium bromide + vilanterol trifenatate work?
Fluticasone furoate reduces airway inflammation. Umeclidinium blocks muscarinic receptors and vilanterol stimulates beta₂ receptors, relaxing and widening the airways through different pathways.
fluticasone furoate + umeclidinium bromide + vilanterol trifenatate preparations and strengths
Inhaled preparation
Route: Inhaled
Strengths: 92 micrograms + 55 micrograms + 22 micrograms
How to take fluticasone furoate + umeclidinium bromide + vilanterol trifenatate
Use only by oral inhalation. Follow the supplied Ellipta instructions and the technique demonstrated by a healthcare professional.
Open the cover only when ready to inhale; do not shake the inhaler.
Breathe out away from the inhaler. Seal your lips around the mouthpiece without covering the air vents, then take one long, steady, deep breath.
Hold your breath briefly if comfortable, then breathe out slowly away from the inhaler.
You may not taste or feel the powder even when it has been inhaled correctly.
Close the cover, then rinse your mouth with water and spit it out.
Clean the mouthpiece with a dry tissue only. Do not breathe into the inhaler.
fluticasone furoate + umeclidinium bromide + vilanterol trifenatate side effects
Common or expected effects
- Mouth or throat thrush
- Colds and infections affecting the nose, sinuses, throat or upper airways
- Bronchitis or pneumonia
- Headache or cough
- Throat discomfort
- Urinary tract infection
- Joint or back pain
- Constipation
Get urgent medical advice
- Allergic reaction with swelling, hives, collapse or breathing difficulty
- Immediate worsening of wheeze or breathlessness after inhalation
- Possible pneumonia: fever, chills, increased or discoloured mucus, worsening cough or breathing
- Eye pain, red eye, blurred vision or visual halos suggesting acute narrow-angle glaucoma
- Difficulty passing urine
- Fast or irregular heartbeat
fluticasone furoate + umeclidinium bromide + vilanterol trifenatate in pregnancy
Evidence for the complete combination in pregnancy is limited. A prescriber should weigh maternal benefit against possible fetal risk. Evidence is reassuring for inhaled corticosteroids such as fluticasone, but does not establish the safety of the full combination.
fluticasone furoate + umeclidinium bromide + vilanterol trifenatate while breastfeeding
It is unknown whether the complete combination or its metabolites enter human milk. The benefits of treatment and breastfeeding require individual assessment. Inhaled fluticasone is considered compatible with breastfeeding, but this evidence does not fully cover umeclidinium and vilanterol.
fluticasone furoate + umeclidinium bromide + vilanterol trifenatate interactions
Ask a prescriber or pharmacist to review other medicines and inhalers, particularly:
Beta-blockers, including propranolol
May oppose vilanterol's bronchodilator effect; concurrent use requires caution.
Strong CYP3A4 inhibitors, including ketoconazole, ritonavir or cobicistat
Can increase exposure to fluticasone and vilanterol and raise the risk of systemic adverse effects.
Other long-acting muscarinic antagonists or long-acting beta₂ agonists
Concurrent use is not recommended because overlapping effects and adverse reactions may be amplified.
Common questions about fluticasone furoate + umeclidinium bromide + vilanterol trifenatate
Answers are fully visible for fast scanning and source review.
What is it used for?
Maintenance treatment for adults with moderate to severe COPD that remains inadequately controlled by specified dual-inhaler combinations.
Is it a steroid inhaler?
Partly. Fluticasone is an inhaled corticosteroid; umeclidinium and vilanterol are long-acting bronchodilators.
Can it relieve sudden breathlessness?
No. It is not a rescue inhaler; sudden symptoms require the prescribed quick-acting reliever.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.