Answer
Ritonavir strongly inhibits CYP3A4, the enzyme responsible for metabolising Trelegy Ellipta’s fluticasone furoate and vilanterol, potentially increasing their systemic exposure and the risk of adverse reactions.
Sources for this answer
- Trelegy Ellipta 92 micrograms/55 micrograms/22 micrograms inhalation powder, pre-dispensedGlaxoSmithKline UK · emc · SmPC §4.5 Interaction with other medicinal products · Version 12Document updated
Sources checked