dibrompropamidine isetionate: clinical use

Prescribing considerations

• Confirm that the condition is a licensed indication suitable for local treatment.
• Avoid prolonged use because it may interfere with healing and cause skin necrosis in infants.
• Consider previous sensitivity to topical creams or ointments and reaction-associated excipients.

Contraindications and cautions

• Known hypersensitivity to dibrompropamidine isetionate or any excipient.

Monitoring

• Assess response and reconsider the diagnosis if the condition worsens or does not improve.
• Stop treatment if sensitisation or contact dermatitis develops.
• No routine laboratory monitoring is specified.

Clinical pharmacology

A topical aromatic diamidine antiseptic active against susceptible streptococci and staphylococci, with some Gram-negative and antifungal activity. Cell-envelope damage and altered permeability contribute to its antibacterial effect; pharmacokinetic data are unavailable.

Formulation and product differences

• The selected licensed product is a smooth white cutaneous cream.
• It contains virgin castor oil, cetostearyl alcohol and methyl parahydroxybenzoate, which may cause local or allergic reactions.
• It is not an ophthalmic preparation.

Cream

Route: Cutaneous

Strengths: 0.15% w/w