aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin at a glance
Type
Fibrin tissue sealant and local haemostatic
Usual role
Adhering or sealing subcutaneous tissue in plastic, reconstructive and burn surgery
Administration
Applied to visible tissue surfaces by a trained surgeon in hospital; it must not be injected
Source materials
Contains human plasma-derived fibrinogen and thrombin, plus synthetic aprotinin and calcium chloride
What is aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin used for?
UK-licensed uses are:
Adhering or sealing subcutaneous tissue in plastic, reconstructive and burn surgery, replacing or supplementing sutures or staples where appropriate
Supporting haemostasis on subcutaneous tissue surfaces
How does aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin work?
Thrombin converts fibrinogen into fibrin, while calcium supports fibrin formation and cross-linking. The resulting clot adheres tissue surfaces; aprotinin slows premature clot breakdown. The sealant is later cleared through processes similar to those that remove natural fibrin.
How to take aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin
This product is not taken by mouth and is not self-administered. A trained surgeon applies the mixed components as a thin layer to a dry, visible subcutaneous tissue surface using the supplied or compatible application system. Spray use requires strict adherence to device instructions and monitoring for embolism.
For topical use on tissue surfaces only; never inject into tissue or blood vessels
Protect surrounding areas to prevent unintended tissue adhesion
Do not use cloudy, discoloured, deposited or gelled solution
Food instructions depend on the planned operation and anaesthetic, not on the sealant itself
aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin side effects
Common or expected effects
- Itching
- Failure of a treated skin graft
Get urgent medical advice
- Severe allergic or anaphylactic reaction
- Air or gas embolism associated with inappropriate spray application
- Blood clots or disseminated intravascular coagulation after accidental intravascular application
- Local tissue damage if injected into soft tissue
aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin in pregnancy
Controlled studies have not established safety during pregnancy. It should be used only when the specialist considers it clearly needed. Because it contains human plasma-derived proteins, the residual infection risk—including particular concern about parvovirus B19 in pregnancy—should be considered.
aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin while breastfeeding
Safety during breastfeeding has not been established in controlled studies. A specialist should decide whether its surgical use is clearly needed.
aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin interactions
Formal interaction studies have not been performed. Important local incompatibilities include:
Alcohol-, iodine- or heavy-metal-containing antiseptic solutions
Contact may denature the sealant, so residues should be removed as far as possible before application.
Oxycellulose-containing haemostatic materials
These may reduce sealant effectiveness and should not be used as carrier materials.
Common questions about aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin
Answers are fully visible for fast scanning and source review.
What is aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin used for?
It is used during plastic, reconstructive and burn surgery to adhere or seal subcutaneous tissue and to support haemostasis on subcutaneous surfaces.
Is aprotinin + calcium chloride dihydrate + human fibrinogen + human thrombin a surgical glue?
Yes. It is a two-component fibrin tissue sealant that forms a clot-like adhesive when its components mix.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.