HIV Pre-Exposure Prophylaxis (PrEP)

Guidelines for PrEP to prevent HIV acquisition.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MSt MRCGP (General Practitioner)

Last reviewed: 21 October 2025

Infectious DiseasesSexual Health

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regional clinical guidance

HIV Pre-Exposure Prophylaxis (PrEP): guidance by region

Recommendations, thresholds and pathways can differ. Open the page written for the jurisdiction you need.

United StatesHIV preexposure prophylaxisPublic health · reviewed 2026-08-20 CanadaHIV PrEP: eligibility, dosing options, baseline tests, and monitoringPublic health · reviewed 2026-08-20 AustraliaHIV PrEP: eligibility, dosing options, baseline tests, and monitoringPublic health · reviewed 2026-08-20

Clinical Guidelines

NICE CKS: HIV infection and AIDS

NICE guideline NG221: HIV testing and prevention

ACOG Practice Advisory: Preexposure Prophylaxis for the Prevention of Human Immunodeficiency Virus

BASHH/BHIVA guidelines on the use of HIV pre-exposure prophylaxis (PrEP) 2025

Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis

CDC Clinical Practice Guideline: Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2021 Update

Guidance on the use of HIV Pre-exposure Prophylaxis (PrEP) in Hong Kong

HIV Prevention Guidelines on Pre-Exposure Prophylaxis (PrEP) | NIH

Pre-exposure Prophylaxis (PrEP) to Prevent HIV During Perinatal Exposure: Clinical Guidelines