How was riociguat exposure affected in HIV patients taking abacavir with dolutegravir and lamivudine?

In HIV patients taking abacavir/dolutegravir/lamivudine 600/50/300 mg once daily, a single 0.5 mg riociguat dose produced approximately three-fold higher riociguat AUC than historical values in healthy subjects; riociguat dose reduction may be needed, following its prescribing information.