Answer
In a pharmacokinetic study, abacavir 600 mg twice daily increased mean methadone systemic clearance by 22%; patients taking both should be monitored for withdrawal symptoms indicating underdosing, as methadone re-titration may occasionally be required.
Sources for this answer
- Abacavir Mylan 300 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §4.5 Interaction with other medicinal products · Version 7Document updated
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