Answer
Irinotecan in Onivyde pegylated liposomal and its active metabolite SN-38 bind reversibly to the topoisomerase I–DNA complex, inducing single-strand DNA lesions that block the DNA replication fork and cause cytotoxicity.
Sources for this answer
- ONIVYDE pegylated liposomal 4.3 mg/ml concentrate for dispersion for infusionServier Laboratories Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 13Document updated
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