Answer
St John's wort may reduce systemic exposure to Onivyde pegylated liposomal through CYP3A4 induction, based on non-liposomal irinotecan data showing AUC reductions of 12% for irinotecan and 42% for its active metabolite SN-38.
Sources for this answer
- ONIVYDE pegylated liposomal 4.3 mg/ml concentrate for dispersion for infusionServier Laboratories Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 13Document updated
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